Sildenafil And How It Works

Silagra drug class: inhibitors of PDE5

role of PDE5 in the erectile mechanismThe active substance in Silagra is sildenafil citrate, a molecule that has a powerful erectogenic action. The class of drugs sildenafil belongs to is called PDE5 inhibitors. PDE5 stands for something called ”phosphodiesterase type 5”, and this is the name of the substance that has several functions in the body related to transmitting signals along the nerve pathways.

What is the role of PDE5 in the erectile mechanism? This enzyme is responsible for the relaxation and contraction of the penile smooth musculature. For an erection to be attained, PDE5 needs to be blocked. Sildenafil is capable of blocking PDE5 by regulating the levels of cGMP (cyclic guanosine monophosphate) and increasing the level of NO (nitric oxide) in the smooth muscles.

The three structures in the shaft of the penis, two cavernous bodies and a spongeous body, are built up by smooth muscle: when these muscles relax, they absorb the blood and trap it inside. This is how an erection is formed. Thus, by expanding the blood vessels in the smooth muscle tissue of the penis, Silagra helps to attain and maintain an erection.

Will Silagra give me spontaneous erections?

According to its design, Silagra acts only in the presence of sexual stimulation. We have described how its active substance helps to form an erection, and you have seen that it acts on the level of signal transmission. This signal comes from the brain, but Silagra is not capable of instigating it: the brain sends the message to activate the erectile function only when the user is sexually aroused.

In practice though, many users of Silagra point out the powerful erectogenic effect of the drug that makes it extremely easy to achieve penile hardness following the slightest erotic stimulus. It should be stressed though that sildenafil has no direct effect on libido, it only improves the mechanics of sexual function.

How does Silagra act long-term?

Sildenafil 100 mgWith continued use, the response to Silagra improves. According to this study, it may take up to 8 doses administered on separate days to achieve the maximal health outcomes with sildenafil.

At the same time, the tolerability of sildenafil, too, becomes better over time, as clinically proven by Dr. Culley C Carson of the University of North Carolina School of Medicine.

The best part of using Silagra long-term is that the drug is capable of restoring the natural ability to achieve and maintain erections in non-medicated state: during this study, 60.4% of men were able to achieve erections a month after discontinuation of sildenafil therapy that had laster 12 months. However, full recovery from ED requires daily dosing with sildenafil.

Understandably, daily intake of Silagra will have to be approved by a doctor, and will entail considerable expenses. Read here how to minimize the cost of Silagra refills.